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Six fire engines and around 40 firefighters were called to reports of smoke at a building on The Strand.
Firefighters extinguished a small fire in the kitchen between the ground and first floors of a restaurant.
Drivers were advised to avoid the local area as road closures were in place. Crews will remain on scene damping down for several hours.
The Brigade was called at 0703 and the incident was under control by 0949. Fire crews from Soho, Lambeth, Dowgate and other surrounding fire stations are at the scene.