Four fire engines and around 25 firefighters were called to a fire at a builders' yard on Carswell Road, Hither Green.
A caravan, motorbike and two cars were destroyed by fire. A small part of a garage was also damaged by fire.
The Brigade was called at 0132 and the fire was under control at 0244. Fire crews from Lewisham, Forest Hill, Lee Green and Greenwich fire stations attended the scene.
The cause of the fire is believed to be accidental due to a halogen spotlight falling and igniting fabric in the caravan.