Six fire engines and 35 firefighters and officers were called to a fire at a hotel and theatre complex on Euston Road.
Part of the ground floor theatre was damaged by fire. Approximately 100 people left the building before the arrival of the Brigade.
The Brigade was called at 1436 and the fire was under control at 1620. Fire crews from Paddington, Soho, Islington, Shoreditch and Kentish Town fire stations attended the scene.
The cause of the fire is under investigation.