Four fire engines and 21 firefighters and officers were called to a fire at a shop with flats above in Station Chambers, Park Royal.
An attic room on the third floor was destroyed by the fire. There were no reports of any injuries.
The Brigade’s 999 control officers took 29 calls to the fire.
The Brigade was called at 2022 and the fire was under control at 2102. Fire crews from Acton, Park Royal, Ealing and Wembley fire stations attended the scene.
The cause of the fire is under investigation.