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Crews tackled a car alight in the Blackwall Tunnel this morning.
Four fire engines and 21 firefighters and officers wearing breathing apparatus tackled the fire. One car was badly damaged in the blaze.
While the fire is under control, local road closures and travel disruption is expected to continue for some time while the scene is cleared.
Four fire engines from Poplar, Millwall and East Greenwich fire stations were at the scene.
The Brigade was called at 1018 and the fire was under control by 1110.