Six fire engines and 35 firefighters and officers were called to a fire at a shop with flats above in Chamberlayne Road, Kensal Rise.
The ground floor was destroyed in the blaze. A small part of the first floor was damaged by fire.
The Brigade was called at 0931 and the fire was under control at 1133. Fire crews from North Kensington, Willesden and Paddington fire stations attended the scene.
The cause of the fire is under investigation.