Ten fire engines and 72 firefighters and officers were called to a fire at a business centre in Salisbury Road, Hounslow.
A restaurant of two floors with a lower ground floor was destroyed by the fire. An adjacent office building of 11 floors was ventilated by crews due to smoke logging on multiple floors.
Ten people left the restaurant before the Brigade arrived and 10 people left the office building. Firefighters led a further eight people to safety. There were no reports of any injuries.
The Brigade’s 999 Control Officers took 27 calls to the blaze.
The Brigade was called at 2256 and the fire was under control at 0053.
Fire crews from Heston, Feltham, Hayes, Twickenham and surrounding fire stations attended the scene as well as colleagues from Surrey Fire and Rescue Service.
The cause of the fire is under investigation.