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Six fire engines and 35 firefighters and officers were called to a fire at a detached house in Horsenden Lane South in Perivale.
Part of the external fascia and guttering was damaged by fire. A range of wooden outbuildings were also completely damaged by the blaze.
The Brigade was called at 0154 and the fire was under control at 0402. Fire crews from Wembley, Northolt, Ealing and Park Royal fire stations attended the scene.
The cause of the fire is under investigation.