Firefighters are attending a serious road traffic collision involving seven motor vehicles on A13 eastbound underpass near Prince Regent Lane in Plaistow.
Two women are trapped by the nature of their injuries. Five men left their vehicles before the Brigade arrived.
A13 Newham Way eastbound between Prince Regent Lane and Beckton Flyover is closed. Please avoid the area if possible.
The Brigade was called at 1316. Fire crews Shadwell, Poplar, East Ham and Bethnal Green fire stations are at the scene.