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Ten fire engines and 72 firefighters and officers have dealt with a blaze in a block of flats on Hicken Road in Brixton.
The fire badly damaged a second floor flat and the fire spread externally to the balconies of the floors above.
Station Manager Jason Jones said: "When firefighters arrived the fire was fully developed and very visible. The initial fire crews worked incredibly hard to fight the fire quickly and limit the damage internally. Thankfully there are no reports of any injuries."
The Brigade was called at 1831 and the fire was under control by 1936. Fire crews from Brixton, Lambeth and surrounding fire stations were at the scene. The cause of the fire is under investigation.