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Three fire engines and 18 firefighters and officers were called to a fire in a flat in Elgin Road, Ilford.
Part of a ground floor flat was damaged by fire.
A man was rescued from the property by firefighters and was taken to hospital by London Ambulance Service crews. Sadly he later died in hospital.
The Brigade was called at 1055 and the fire was under control at 1226.
The cause of the fire is under investigation by the Brigade.