Four fire engines and 21 firefighters and officers were called to a fire at a flat in Amhurst Road, Hackney on Sunday.
Part of a flat on the second floor and part of the roof were damaged by fire.
Three people left the property before the arrival of the Brigade. There were no reports of any injuries.
The Brigade was called at 0050 and the fire was under control at 0316. Fire crews from Homerton, Bethnal Green and Stoke Newington fire stations attended the scene.
The cause of the fire is under investigation.